Scientific Publications

Scientific Manuscripts

A Selection from >200 Peer-Reviewed Publications by OCS Investigators

You will need Adobe Acrobat Reader to open some of the available papers.
Download Adobe Acrobat Reader for free: Download Acrobat
  1. Genkinger JM, Spiegelman D, Anderson KE, Bernstein L, van den Brandt PA, Calle EE, English DR, Folsom AR, Freudenheim JL, Fuchs CS, Giles GG, Giovannucci E, Horn-Ross PL, Larsson SC, Leitzmann M, Männistö S, Marshall JR, Miller AB, Patel AV, Rohan TE, Stolzenberg-Solomon RZ, Verhage BA, Virtamo J, Willcox BJ, Wolk A, Ziegler RG, Smith-Warner SA. A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. Int J Cancer. 2011 Oct 1;129(7):1708-17. doi: 10.1002/ijc.25794. Epub 2011 Mar 4. Abstract.
  2. Shikany JM, Flood AP, Kitahara CM, Hsing AW, Meyer TE, Willcox BJ, Redden DT, Ziegler RG. Dietary carbohydrate, glycemic index, glycemic load, and risk of prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Cancer Causes Control. 2011 Jul;22(7):995-1002. Epub 2011 May 7. Abstract.
  3. Rantanen T, Masaki K, He Q, Ross GW, Willcox BJ, White L. Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort. Age (Dordr). 2011 May 4. [Epub ahead of print] Abstract.
  4. Berrington de Gonzalez A, Hartge P, Cerhan JR, Flint AJ, Hannan L, MacInnis RJ, Moore SC, Tobias GS, Anton-Culver H, Freeman LB, Beeson WL, Clipp SL, English DR, Folsom AR, Freedman DM, Giles G, Hakansson N, Henderson KD, Hoffman-Bolton J, Hoppin JA, Koenig KL, Lee IM, Linet MS, Park Y, Pocobelli G, Schatzkin A, Sesso HD, Weiderpass E, Willcox BJ, Wolk A, Zeleniuch-Jacquotte A, Willett WC, Thun MJ. Body-mass index and mortality among 1.46 million white adults. N Engl J Med. 2010 Dec 2;363(23):2211-9. Erratum in: N Engl J Med. 2011 Sep 1;365(9):869. PDF.
  5. Rosenbaum MW, Willcox BJ, Willcox DC,Suzuki M: Okinawa: a naturally calorie restricted population; In Everitt AV (Ed): Calorie Restriction, Aging and Longevity. Springer, Dordrecht,Netherlands, p.43-53, 2010. Book.
  6. Dodge HH, Katsumata Y, Todoriki H, Yasura S, Willcox DC, Bowman GL, Willcox B, Leonard S, Clemons A, Oken BS, Kaye JA, Traber MG. Comparisons of plasma/serum micronutrients between Okinawan and Oregonian elders: a pilot study. J Gerontol A Biol Sci Med Sci. 2010 Oct;65(10):1060-7. Epub 2010 Jul 19. PDF.
  7. Willcox DC, Willcox BJ, Poon LW. Centenarian studies: important contributors to our understanding of the aging process and longevity. Curr Gerontol Geriatr Res. 2010;2010:484529. Epub 2011 Jul 13. PDF.
  8. Suzuki M, Willcox DC, Rosenbaum MW, Willcox BJ. Oxidative stress and longevity in okinawa: an investigation of blood lipid peroxidation and tocopherol in okinawan centenarians. Curr Gerontol Geriatr Res. 2010;2010:380460. Epub 2011 Mar 30. PDF.
  9. Ceria-Ulep CD, Grove J, Chen R, Masaki KH, Rodriguez BL, Donlon TA, Guralnik J, Willcox BJ, Willcox DC, Nigg C, Curb JD. Physical aspects of healthy aging: assessments of three measures of balance for studies in middle-aged and older adults. Curr Gerontol Geriatr Res. 2010;2010:849761. Epub 2011 Mar 3. PDF.
  10. Willcox DC, Willcox BJ, Rosenbaum M, Sokolovsky J, Suzuki M: Exceptional Longevity and the Quest for Healthy Aging: Insights from the Okinawa Centenarian In: Sokolovsky J. (Ed.). The Cultural Context of Aging:Worldwide Perspectives. Praeger, London, p. 505-532, 2009. Book.
  11. Willcox DC and Willcox BJ. FOXO3A Genotype and Human Longevity: The New APOE? Japanese Journal of Anti-Aging Medicine 2009;5(6):804-809. PDF.
  12. He Q, Willcox BJ. Linkage disequilibrium of single-nucleotide polymorphism data: how sampling methods affect estimates of linkage disequilibrium. BMC Proc. 2009 Dec 15;3 Suppl 7:S105. PDF.
  13. Sue LY, Schairer C, Ma X, Williams C, Chang SC, Miller AB, McCarty CA, Willcox BJ, Ziegler RG. Energy intake and risk of postmenopausal breast cancer: an expanded analysis in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2842-50. Epub 2009 Oct 20. PDF.
  14. Willcox DC, Willcox BJ, Todoriki H, Suzuki M. The Okinawan diet: health implications of a low-calorie, nutrient-dense, antioxidant-rich dietary pattern low in glycemic load. J Am Coll Nutr. 2009 Aug;28 Suppl:500S-516S. Review. PDF.
  15. Motoyama KR, Curb JD, Kadowaki T, El-Saed A, Abbott RD, Okamura T, Evans RW, Nakamura Y, Sutton-Tyrrell K, Rodriquez BL, Kadota A, Edmundowicz D, Willcox BJ, Choo J, Katsumi N, Otake T, Kadowaki S, Kuller LH, Ueshima H, Sekikawa A. Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men. Am J Clin Nutr. 2009 Jul;90(1):49-55. Epub 2009 May 27. PDF.
  16. Koropatnick TA, Kimbell J, Chen R, Grove JS, Donlon TA, Masaki KH, Rodriguez BL, Willcox BJ, Yano K, Curb JD. A prospective study of high-density lipoprotein cholesterol, cholesteryl ester transfer protein gene variants, and healthy aging in very old Japanese-american men. J Gerontol A Biol Sci Med Sci. 2008 Nov;63(11):1235-40. Abstract.
  17. Willcox BJ, Willcox DC, Ferrucci L. Secrets of healthy aging and longevity from exceptional survivors around the globe: lessons from octogenarians to supercentenarians. J Gerontol A Biol Sci Med Sci. 2008 Nov;63(11):1181-5. Abstract.
  18. Willcox BJ, Donlon TA, He Q, Chen R, Grove JS, Yano K, Masaki KH, Willcox DC, Rodriguez B, Curb JD. FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13987-92. Epub 2008 Sep 2. PDF.
  19. Sekikawa A, Curb JD, Ueshima H, El-Saed A, Kadowaki T, Abbott RD, Evans RW, Rodriguez BL, Okamura T, Sutton-Tyrrell K, Nakamura Y, Masaki K, Edmundowicz D, Kashiwagi A, Willcox BJ, Takamiya T, Mitsunami K, Seto TB, Murata K, White RL, Kuller LH; ERA JUMP (Electron-Beam Tomography, Risk Factor Assessment Among Japanese and U.S. Men in the Post-World War II Birth Cohort) Study Group. Marine-derived n-3 fatty acids and atherosclerosis in Japanese, Japanese-American, and white men: a cross-sectional study. J Am Coll Cardiol. 2008 Aug 5;52(6):417-24. PDF.
  20. Willcox BJ, Curb JD, Rodriguez BL. Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies. Am J Cardiol 2008 Abstract.
  21. Suzuki M, Willcox C, Willcox B. The historical context of Okinawan longevity: influence of the United States and Mainland Japan. Okinawan J Am Studies 2008;4:46-61 PDF.
  22. Willcox BJ, Willcox DC, Todoriki H, Yano K, Curb JD, Suzuki M. Caloric restriction, energy balance and healthy aging in Okinawans and Americans: biomarker differences in septuagenarians. Okinawan J Am Studies 2008;4:62-74.PDF
  23. Willcox DC, Willcox BJ, Wang T, Rosenbaum M, Suzuki M. Life at the Extreme Limit: Phenotypic Characteristics of Supercentenarians in Okinawa. J Gerontol: Biol Med Sci 2008 PDF
  24. Willcox DC, Willcox BJ, He Q, Wang N-C, Suzuki M. They Really are that Old: A Validation Study of Centenarian Prevalence in Okinawa. Journal of Gerontology: Biological Sciences 2008; Vol. 63A, No. 4, 338–349 PDF.
  25. Willcox BJ, Willcox DC, Todoriki H, Fujiyoshi A, Yano K, he Q, Curb JD, Suzuki M. Caloric restriction, the traditional Okinawan diet and healthy aging: the diet of the world's longest-lived people and its potential impact on morbidity and lifespan. Ann N Y Acad Sci 2007;1114:434-55. PDF
  26. Willcox DC, Willcox BJ, Sokolovsky J, Sakihara S. The cultural context of "successful aging" among older women weavers in a northern Okinawan village: The role of productive activity. J Cross Cult Gerontol. 2007;22:137-65. PDF
  27. Willcox DC, Willcox BJ, Shimajiri S, Kurechi S, Suzuki M. Aging gracefully: a retrospective analysis of functional status in Okinawan centenarians. Am J Geriatr Psychiatry. 2007;15:252-6. PDF
  28. Yanagita M, Willcox BJ, Masaki K, Chen R, He Q, Rodriguez BL, Ueshima H, Curb JD. Physical activity and depression: investigating a complex relationship using performance-based measures. Am J Geriatr Psych 2006;14:1060-8. PDF
  29. Willcox BJ. (Editorial). Centenarians and other exceptional survivors as models for aging research. AGE 2006;28:309-11.PDF
  30. Willcox DC, Willcox BJ, Hsueh W, Suzuki M. Genetic determinants of exceptional human longevity: insights from the Okinawa Centenarian Study. AGE 2006;28:313-32. PDF
  31. Willcox BJ, He Q, Chen R, Yano K, Masaki KH, Grove JS, Donlon TA, Willcox DC, Curb JD. Midlife risk factors and healthy survival in men. JAMA 2006;296:2343-2350. PDF
  32. Willcox DC, Willcox BJ, Todoriki H, Curb JD, Suzuki M. Caloric restriction and human longevity: what can we learn from the Okinawans? Biogerontology 2006;7:173-177. (PDF)
  33. Curb JD, Ceria-Ulep CD, Rodriguez BL, Grove J, Guralnik J, Willcox BJ, Masaki KH, Chen R. Performance based measures of physical function for high function populations. J Am Geriatr Soc. 2006;54:737-42. (Abstract)
  34. Willcox BJ, Willcox DC, He Q, Curb JD, Suzuki M. Siblings of Okinawan centenarians exhibit lifelong mortality advantages. J Gerontol A Biol Med Sci. 2006;61:345-54. (PDF)
  35. Imke C, Rodriguez BL, Grove JS, McNamara JR, Waslien C, Katz AR, Willcox BJ, Yano K, Curb JD. Are remnant-like particles independent predictors of coronary heart disease incidence? The Honolulu Heart Study. Arterioscler Thromb Vasc Biol. 2005;25:1718-22. PDF
  36. Bernstein AM, Willcox BJ, Tamaki H, Kunishima N, et al. Autopsy of an Okinawan-Japanese centenarian: absence of many age-related diseases. J Gerontol A Biol Sci Med Sci. 2004;59:1195-9. PDF
  37. Willcox BJ, Yano K, Chen R, Willcox DC, Rodriguez BL, Masaki KH, Donlon T, Tanaka B, Curb JD. How much should we eat? The association between energy intake and mortality in a 36-year follow-up study of Japanese-American men in Hawaii. J Gerontol A Biol Sci Med Sci. 2004;59:789-95. PDF
  38. Willcox BJ, Scott JN. Growth associated proteins and regeneration-induced gene expression in the aging neuron. Mech Age Dev. 2004;125:513-16. PDF
  39. Willcox BJ, Abbott RD, Yano K, Rodriguez BL, Willcox DC, Curb JD. C-reactive protein, cardiovascular disease and stroke: new roles for an old biomarker. Expert Rev Neurotherapeutics 2004;4:507-18. (Abstract)
  40. Willcox BJ, Abbott RD, Yano K, Rodriguez BL, Willcox DC, Tanaka B, Curb JD. C-reactive protein as a novel risk factor for cardiovascular disease: is it ready for prime time? Cardiovascular Rev Rep. 2004;25:66-9. (Abstract-you will need to register to view)
  41. Todoriki H, Willcox DC, Willcox BJ. The Effects of Post-War Dietary change on longevity and health in Okinawa. Oki J Amer Studies 2004;1:55-64. PDF
  42. Yano K, Willcox B, Chen R, Rodriguez B, Curb JD. The impact of westernization on the risk of atherosclerotic vascular disease among Japanese-American men in Hawaii. Atheroscler Suppl 2003;4:7. Abstract
  43. Willcox BJ, DC Willcox, Suzuki M. Nutrition and aging in Okinawa: is there a diet that extends health span? J Am Diet Assoc Pulse (CPE) 2001;20:5-8. PDF
  44. Suzuki M, Willcox BJ, Willcox DC. Implications from and for food cultures for cardiovascular disease: longevity. Asia Pacific J Clin Nutr 2001;10:165-71. PDF
  45. Nozaki H, Nohara Y, Ashitomi I, Zukeran R, Inafuku T, Akisaka M, Suzuki M. [Serum albumin level and activities of daily living in centenarians] Nippon Ronen Igakkai Zasshi. 1998;35:741-7. Japanese. (Abstract)
  46. Nozaki H, Nohara Y, Ashitomi I, Zukeran R, Inafuku T, Akisaka M, Suzuki M. [Serum globulin levels and activities of daily living in centenarians] Nippon Ronen Igakkai Zasshi. 1998;35:680-5. Japanese. (Abstract)
  47. Akisaka M, Suzuki M. [Okinawa Longevity Study. Molecular genetic analysis of HLA genes in the very old] Nippon Ronen Igakkai Zasshi. 1998;35:294-8. Japanese. (Abstract)
  48. Akisaka M, Suzuki M, Inoko H. Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity. Tissue Antigens. 1997;50:489-93. (Abstract)
  49. Chan YC, Suzuki M, Yamamoto S. Dietary, anthropometric, hematological and biochemical assessment of the nutritional status of centenarians and elderly people in Okinawa, Japan. J Am Coll Nutr. 1997;16:229-35. (Abstract)
  50. Chan YC, Suzuki M, Yamamoto S. Nutritional status of centenarians assessed by activity and anthropometric, hematological and biochemical characteristics. Nutr Sci Vitaminol (Tokyo). 1997;43:73-81. (PDF)
  51. Akisaka M, Asato L, Chan YC, Suzuki M, Uezato T, Yamamoto S. Energy and nutrient intakes of Okinawan centenarians.J Nutr Sci Vitaminol (Tokyo). 1996;42:241-8. (PDF)
  52. Akisaka M, Nohara Y, Suzuki M. [Family history and the frequency of human leukocyte antigen (HLA-DR) in centenarians] Nippon Ronen Igakkai Zasshi. 1996;33:180-5. Japanese. (Abstract)
  53. Akisaka M, Asato L, Suzuki M, et al. Relationship between bone density and nutrient intakes of Okinawan centenarians. Osteoporosis 1996;4:503-509.
  54. Suzuki M, Akisaka M, Ashitomi I, Higa K, Nozaki H. [Chronological study concerning ADL among Okinawan centenarians] Nippon Ronen Igakkai Zasshi. 1995;32:416-23. Japanese. (Abstract)
  55. Koibuchi H, Hayakawa K, Uehara T, Ogido T, Nagataki S, Suzuki M. [Anterior chamber dimensions in normal subjects on Kume Island, Okinawa] Nippon Ganka Gakkai Zasshi. 1993;97:1185-92. Japanese. (Abstract)
  56. Akisaka M, Ashitomi I, Adachi M, Tanaka Y, Suzuki M. [The relationship between aortic pulse wave velocity and atherogenic index in centenarians] Nippon Ronen Igakkai Zasshi. 1993;30:467-73. Japanese.(Abstract)
  57. Takata H, Suzuki M, Ishii T, Sekiguchi S, Iri H. Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians.Lancet. 1987;2(8563):824-6.(Abstract)